Pesquisa | BVS IEC

1.

Respiratory mucosal delivery of next-generation COVID-19 vaccine provides robust protection against both ancestral and variant strains of SARS-CoV-2.

Afkhami, Sam; D'Agostino, Michael R; Zhang, Ali; Stacey, Hannah D; Marzok, Art; Kang, Alisha; Singh, Ramandeep; Bavananthasivam, Jegarubee; Ye, Gluke; Luo, Xiangqian; Wang, Fuan; Ang, Jann C; Zganiacz, Anna; Sankar, Uma; Kazhdan, Natallia; Koenig, Joshua F E; Phelps, Allyssa; Gameiro, Steven F; Tang, Shangguo; Jordana, Manel; Wan, Yonghong; Mossman, Karen L; Jeyanathan, Mangalakumari; Gillgrass, Amy; Medina, Maria Fe C; Smaill, Fiona; Lichty, Brian D; Miller, Matthew S; Xing, Zhou.

Cell ; 185(5): 896-915.e19, 2022 03 03.

Artigo em Inglês | MEDLINE | ID: mdl-35180381

2.

Seasonal human coronavirus antibodies are boosted upon SARS-CoV-2 infection but not associated with protection.

Anderson, Elizabeth M; Goodwin, Eileen C; Verma, Anurag; Arevalo, Claudia P; Bolton, Marcus J; Weirick, Madison E; Gouma, Sigrid; McAllister, Christopher M; Christensen, Shannon R; Weaver, JoEllen; Hicks, Philip; Manzoni, Tomaz B; Oniyide, Oluwatosin; Ramage, Holly; Mathew, Divij; Baxter, Amy E; Oldridge, Derek A; Greenplate, Allison R; Wu, Jennifer E; Alanio, Cécile; D'Andrea, Kurt; Kuthuru, Oliva; Dougherty, Jeanette; Pattekar, Ajinkya; Kim, Justin; Han, Nicholas; Apostolidis, Sokratis A; Huang, Alex C; Vella, Laura A; Kuri-Cervantes, Leticia; Pampena, M Betina; Betts, Michael R; Wherry, E John; Meyer, Nuala J; Cherry, Sara; Bates, Paul; Rader, Daniel J; Hensley, Scott E.

Cell ; 184(7): 1858-1864.e10, 2021 04 01.

Artigo em Inglês | MEDLINE | ID: mdl-33631096

3.

Reduced neutralization of SARS-CoV-2 B.1.1.7 variant by convalescent and vaccine sera.

Supasa, Piyada; Zhou, Daming; Dejnirattisai, Wanwisa; Liu, Chang; Mentzer, Alexander J; Ginn, Helen M; Zhao, Yuguang; Duyvesteyn, Helen M E; Nutalai, Rungtiwa; Tuekprakhon, Aekkachai; Wang, Beibei; Paesen, Guido C; Slon-Campos, Jose; López-Camacho, César; Hallis, Bassam; Coombes, Naomi; Bewley, Kevin R; Charlton, Sue; Walter, Thomas S; Barnes, Eleanor; Dunachie, Susanna J; Skelly, Donal; Lumley, Sheila F; Baker, Natalie; Shaik, Imam; Humphries, Holly E; Godwin, Kerry; Gent, Nick; Sienkiewicz, Alex; Dold, Christina; Levin, Robert; Dong, Tao; Pollard, Andrew J; Knight, Julian C; Klenerman, Paul; Crook, Derrick; Lambe, Teresa; Clutterbuck, Elizabeth; Bibi, Sagida; Flaxman, Amy; Bittaye, Mustapha; Belij-Rammerstorfer, Sandra; Gilbert, Sarah; Hall, David R; Williams, Mark A; Paterson, Neil G; James, William; Carroll, Miles W; Fry, Elizabeth E; Mongkolsapaya, Juthathip.

Cell ; 184(8): 2201-2211.e7, 2021 04 15.

Artigo em Inglês | MEDLINE | ID: mdl-33743891

4.

COVID-19-neutralizing antibodies predict disease severity and survival.

Garcia-Beltran, Wilfredo F; Lam, Evan C; Astudillo, Michael G; Yang, Diane; Miller, Tyler E; Feldman, Jared; Hauser, Blake M; Caradonna, Timothy M; Clayton, Kiera L; Nitido, Adam D; Murali, Mandakolathur R; Alter, Galit; Charles, Richelle C; Dighe, Anand; Branda, John A; Lennerz, Jochen K; Lingwood, Daniel; Schmidt, Aaron G; Iafrate, A John; Balazs, Alejandro B.

Cell ; 184(2): 476-488.e11, 2021 01 21.

Artigo em Inglês | MEDLINE | ID: mdl-33412089

5.

B cell genomics behind cross-neutralization of SARS-CoV-2 variants and SARS-CoV.

Scheid, Johannes F; Barnes, Christopher O; Eraslan, Basak; Hudak, Andrew; Keeffe, Jennifer R; Cosimi, Lisa A; Brown, Eric M; Muecksch, Frauke; Weisblum, Yiska; Zhang, Shuting; Delorey, Toni; Woolley, Ann E; Ghantous, Fadi; Park, Sung-Moo; Phillips, Devan; Tusi, Betsabeh; Huey-Tubman, Kathryn E; Cohen, Alexander A; Gnanapragasam, Priyanthi N P; Rzasa, Kara; Hatziioanno, Theodora; Durney, Michael A; Gu, Xiebin; Tada, Takuya; Landau, Nathaniel R; West, Anthony P; Rozenblatt-Rosen, Orit; Seaman, Michael S; Baden, Lindsey R; Graham, Daniel B; Deguine, Jacques; Bieniasz, Paul D; Regev, Aviv; Hung, Deborah; Bjorkman, Pamela J; Xavier, Ramnik J.

Cell ; 184(12): 3205-3221.e24, 2021 06 10.

Artigo em Inglês | MEDLINE | ID: mdl-34015271

6.

A Single-Dose Intranasal ChAd Vaccine Protects Upper and Lower Respiratory Tracts against SARS-CoV-2.

Hassan, Ahmed O; Kafai, Natasha M; Dmitriev, Igor P; Fox, Julie M; Smith, Brittany K; Harvey, Ian B; Chen, Rita E; Winkler, Emma S; Wessel, Alex W; Case, James Brett; Kashentseva, Elena; McCune, Broc T; Bailey, Adam L; Zhao, Haiyan; VanBlargan, Laura A; Dai, Ya-Nan; Ma, Meisheng; Adams, Lucas J; Shrihari, Swathi; Danis, Jonathan E; Gralinski, Lisa E; Hou, Yixuan J; Schäfer, Alexandra; Kim, Arthur S; Keeler, Shamus P; Weiskopf, Daniela; Baric, Ralph S; Holtzman, Michael J; Fremont, Daved H; Curiel, David T; Diamond, Michael S.

Cell ; 183(1): 169-184.e13, 2020 10 01.

Artigo em Inglês | MEDLINE | ID: mdl-32931734

7.

Imbalance of Regulatory and Cytotoxic SARS-CoV-2-Reactive CD4⁺ T Cells in COVID-19.

Meckiff, Benjamin J; Ramírez-Suástegui, Ciro; Fajardo, Vicente; Chee, Serena J; Kusnadi, Anthony; Simon, Hayley; Eschweiler, Simon; Grifoni, Alba; Pelosi, Emanuela; Weiskopf, Daniela; Sette, Alessandro; Ay, Ferhat; Seumois, Grégory; Ottensmeier, Christian H; Vijayanand, Pandurangan.

Cell ; 183(5): 1340-1353.e16, 2020 11 25.

Artigo em Inglês | MEDLINE | ID: mdl-33096020

8.

Antigen-Specific Adaptive Immunity to SARS-CoV-2 in Acute COVID-19 and Associations with Age and Disease Severity.

Rydyznski Moderbacher, Carolyn; Ramirez, Sydney I; Dan, Jennifer M; Grifoni, Alba; Hastie, Kathryn M; Weiskopf, Daniela; Belanger, Simon; Abbott, Robert K; Kim, Christina; Choi, Jinyong; Kato, Yu; Crotty, Eleanor G; Kim, Cheryl; Rawlings, Stephen A; Mateus, Jose; Tse, Long Ping Victor; Frazier, April; Baric, Ralph; Peters, Bjoern; Greenbaum, Jason; Ollmann Saphire, Erica; Smith, Davey M; Sette, Alessandro; Crotty, Shane.

Cell ; 183(4): 996-1012.e19, 2020 11 12.

Artigo em Inglês | MEDLINE | ID: mdl-33010815

9.

Mapping Systemic Inflammation and Antibody Responses in Multisystem Inflammatory Syndrome in Children (MIS-C).

Gruber, Conor N; Patel, Roosheel S; Trachtman, Rebecca; Lepow, Lauren; Amanat, Fatima; Krammer, Florian; Wilson, Karen M; Onel, Kenan; Geanon, Daniel; Tuballes, Kevin; Patel, Manishkumar; Mouskas, Konstantinos; O'Donnell, Timothy; Merritt, Elliot; Simons, Nicole W; Barcessat, Vanessa; Del Valle, Diane M; Udondem, Samantha; Kang, Gurpawan; Gangadharan, Sandeep; Ofori-Amanfo, George; Laserson, Uri; Rahman, Adeeb; Kim-Schulze, Seunghee; Charney, Alexander W; Gnjatic, Sacha; Gelb, Bruce D; Merad, Miriam; Bogunovic, Dusan.

Cell ; 183(4): 982-995.e14, 2020 11 12.

Artigo em Inglês | MEDLINE | ID: mdl-32991843

10.

Case Study: Prolonged Infectious SARS-CoV-2 Shedding from an Asymptomatic Immunocompromised Individual with Cancer.

Avanzato, Victoria A; Matson, M Jeremiah; Seifert, Stephanie N; Pryce, Rhys; Williamson, Brandi N; Anzick, Sarah L; Barbian, Kent; Judson, Seth D; Fischer, Elizabeth R; Martens, Craig; Bowden, Thomas A; de Wit, Emmie; Riedo, Francis X; Munster, Vincent J.

Cell ; 183(7): 1901-1912.e9, 2020 12 23.

Artigo em Inglês | MEDLINE | ID: mdl-33248470

11.

Mapping Neutralizing and Immunodominant Sites on the SARS-CoV-2 Spike Receptor-Binding Domain by Structure-Guided High-Resolution Serology.

Piccoli, Luca; Park, Young-Jun; Tortorici, M Alejandra; Czudnochowski, Nadine; Walls, Alexandra C; Beltramello, Martina; Silacci-Fregni, Chiara; Pinto, Dora; Rosen, Laura E; Bowen, John E; Acton, Oliver J; Jaconi, Stefano; Guarino, Barbara; Minola, Andrea; Zatta, Fabrizia; Sprugasci, Nicole; Bassi, Jessica; Peter, Alessia; De Marco, Anna; Nix, Jay C; Mele, Federico; Jovic, Sandra; Rodriguez, Blanca Fernandez; Gupta, Sneha V; Jin, Feng; Piumatti, Giovanni; Lo Presti, Giorgia; Pellanda, Alessandra Franzetti; Biggiogero, Maira; Tarkowski, Maciej; Pizzuto, Matteo S; Cameroni, Elisabetta; Havenar-Daughton, Colin; Smithey, Megan; Hong, David; Lepori, Valentino; Albanese, Emiliano; Ceschi, Alessandro; Bernasconi, Enos; Elzi, Luigia; Ferrari, Paolo; Garzoni, Christian; Riva, Agostino; Snell, Gyorgy; Sallusto, Federica; Fink, Katja; Virgin, Herbert W; Lanzavecchia, Antonio; Corti, Davide; Veesler, David.

Cell ; 183(4): 1024-1042.e21, 2020 11 12.

Artigo em Inglês | MEDLINE | ID: mdl-32991844

12.

BNT162b2 vaccine induces divergent B cell responses to SARS-CoV-2 S1 and S2.

Brewer, R Camille; Ramadoss, Nitya S; Lahey, Lauren J; Jahanbani, Shaghayegh; Robinson, William H; Lanz, Tobias V.

Nat Immunol ; 23(1): 33-39, 2022 01.

Artigo em Inglês | MEDLINE | ID: mdl-34848871

13.

Prolonged activation of nasal immune cell populations and development of tissue-resident SARS-CoV-2-specific CD8⁺ T cell responses following COVID-19.

Roukens, Anna H E; Pothast, Cilia R; König, Marion; Huisman, Wesley; Dalebout, Tim; Tak, Tamar; Azimi, Shohreh; Kruize, Yvonne; Hagedoorn, Renate S; Zlei, Mihaela; Staal, Frank J T; de Bie, Fenna J; van Dongen, Jacques J M; Arbous, Sesmu M; Zhang, Jaimie L H; Verheij, Maaike; Prins, Corine; van der Does, Anne M; Hiemstra, Pieter S; de Vries, Jutte J C; Janse, Jacqueline J; Roestenberg, Meta; Myeni, Sebenzile K; Kikkert, Marjolein; Yazdanbakhsh, Maria; Heemskerk, Mirjam H M; Smits, Hermelijn H; Jochems, Simon P.

Nat Immunol ; 23(1): 23-32, 2022 01.

Artigo em Inglês | MEDLINE | ID: mdl-34937933

14.

Distinct systemic and mucosal immune responses during acute SARS-CoV-2 infection.

Smith, Nikaïa; Goncalves, Pedro; Charbit, Bruno; Grzelak, Ludivine; Beretta, Maxime; Planchais, Cyril; Bruel, Timothée; Rouilly, Vincent; Bondet, Vincent; Hadjadj, Jérôme; Yatim, Nader; Pere, Helene; Merkling, Sarah H; Ghozlane, Amine; Kernéis, Solen; Rieux-Laucat, Frederic; Terrier, Benjamin; Schwartz, Olivier; Mouquet, Hugo; Duffy, Darragh; Di Santo, James P.

Nat Immunol ; 22(11): 1428-1439, 2021 11.

Artigo em Inglês | MEDLINE | ID: mdl-34471264

15.

Robust SARS-CoV-2-specific T cell immunity is maintained at 6 months following primary infection.

Zuo, Jianmin; Dowell, Alexander C; Pearce, Hayden; Verma, Kriti; Long, Heather M; Begum, Jusnara; Aiano, Felicity; Amin-Chowdhury, Zahin; Hoschler, Katja; Brooks, Tim; Taylor, Stephen; Hewson, Jacqueline; Hallis, Bassam; Stapley, Lorrain; Borrow, Ray; Linley, Ezra; Ahmad, Shazaad; Parker, Ben; Horsley, Alex; Amirthalingam, Gayatri; Brown, Kevin; Ramsay, Mary E; Ladhani, Shamez; Moss, Paul.

Nat Immunol ; 22(5): 620-626, 2021 05.

Artigo em Inglês | MEDLINE | ID: mdl-33674800

16.

ORF8 and ORF3b antibodies are accurate serological markers of early and late SARS-CoV-2 infection.

Hachim, Asmaa; Kavian, Niloufar; Cohen, Carolyn A; Chin, Alex W H; Chu, Daniel K W; Mok, Chris K P; Tsang, Owen T Y; Yeung, Yiu Cheong; Perera, Ranawaka A P M; Poon, Leo L M; Peiris, J S Malik; Valkenburg, Sophie A.

Nat Immunol ; 21(10): 1293-1301, 2020 10.

Artigo em Inglês | MEDLINE | ID: mdl-32807944

17.

Recurrent Potent Human Neutralizing Antibodies to Zika Virus in Brazil and Mexico.

Robbiani, Davide F; Bozzacco, Leonia; Keeffe, Jennifer R; Khouri, Ricardo; Olsen, Priscilla C; Gazumyan, Anna; Schaefer-Babajew, Dennis; Avila-Rios, Santiago; Nogueira, Lilian; Patel, Roshni; Azzopardi, Stephanie A; Uhl, Lion F K; Saeed, Mohsan; Sevilla-Reyes, Edgar E; Agudelo, Marianna; Yao, Kai-Hui; Golijanin, Jovana; Gristick, Harry B; Lee, Yu E; Hurley, Arlene; Caskey, Marina; Pai, Joy; Oliveira, Thiago; Wunder, Elsio A; Sacramento, Gielson; Nery, Nivison; Orge, Cibele; Costa, Federico; Reis, Mitermayer G; Thomas, Neena M; Eisenreich, Thomas; Weinberger, Daniel M; de Almeida, Antonio R P; West, Anthony P; Rice, Charles M; Bjorkman, Pamela J; Reyes-Teran, Gustavo; Ko, Albert I; MacDonald, Margaret R; Nussenzweig, Michel C.

Cell ; 169(4): 597-609.e11, 2017 May 04.

Artigo em Inglês | MEDLINE | ID: mdl-28475892

18.

Vaccine Mediated Protection Against Zika Virus-Induced Congenital Disease.

Richner, Justin M; Jagger, Brett W; Shan, Chao; Fontes, Camila R; Dowd, Kimberly A; Cao, Bin; Himansu, Sunny; Caine, Elizabeth A; Nunes, Bruno T D; Medeiros, Daniele B A; Muruato, Antonio E; Foreman, Bryant M; Luo, Huanle; Wang, Tian; Barrett, Alan D; Weaver, Scott C; Vasconcelos, Pedro F C; Rossi, Shannan L; Ciaramella, Giuseppe; Mysorekar, Indira U; Pierson, Theodore C; Shi, Pei-Yong; Diamond, Michael S.

Cell ; 170(2): 273-283.e12, 2017 Jul 13.

Artigo em Inglês | MEDLINE | ID: mdl-28708997

19.

Zika Virus: Immunity and Vaccine Development.

Pierson, Theodore C; Graham, Barney S.

Cell ; 167(3): 625-631, 2016 Oct 20.

Artigo em Inglês | MEDLINE | ID: mdl-27693357

20.

COVID-19 immune signatures reveal stable antiviral T cell function despite declining humoral responses.

Bonifacius, Agnes; Tischer-Zimmermann, Sabine; Dragon, Anna C; Gussarow, Daniel; Vogel, Alexander; Krettek, Ulrike; Gödecke, Nina; Yilmaz, Mustafa; Kraft, Anke R M; Hoeper, Marius M; Pink, Isabell; Schmidt, Julius J; Li, Yang; Welte, Tobias; Maecker-Kolhoff, Britta; Martens, Jörg; Berger, Marc Moritz; Lobenwein, Corinna; Stankov, Metodi V; Cornberg, Markus; David, Sascha; Behrens, Georg M N; Witzke, Oliver; Blasczyk, Rainer; Eiz-Vesper, Britta.

Immunity ; 54(2): 340-354.e6, 2021 02 09.

Artigo em Inglês | MEDLINE | ID: mdl-33567252

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Instituto Evandro Chagas

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